منابع مشابه
Transient Dimers of Allergens
BACKGROUND Allergen-mediated cross-linking of IgE antibodies bound to the FcepsilonRI receptors on the mast cell surface is the key feature of the type I allergy. If an allergen is a homodimer, its allergenicity is enhanced because it would only need one type of antibody, instead of two, for cross-linking. METHODOLOGY/PRINCIPAL FINDINGS An analysis of 55 crystal structures of allergens showed...
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Density functional (DFT) calculations at M05-2x/aug-cc-pVDZ level were used to analyze the interactions between dimethyl sulfoxide (DMSO) dimers. The structures obtained have been analyzed with the Atoms in Molecules (AIMs) and Natural Bond Orbital (NBO) methodologies. Four minima were located on the potential energy surface of the dimers. Three types of interactions are observed, CH•••O, CH•••...
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Advances in the techniques used to study allergic patients have allowed us to recognize multiple mistakes made in the past, and thus to avoid prescribing patient immunotherapy treatments that are not fully valid. One of the major achievements has been the molecular diagnosis of allergic diseases. In effect, while in the past we only had gross determinations of specific IgE to pollens, we can no...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0009037